I’ve had really good luck with Pop!_OS. AMD CPU and NVIDIA GPU, so having the NVIDIA drivers bundled is nice.

Most games in my Steam library work out of the box with no tinkering of Proton. I’ve lucked out in that the games that do require tinkering work with Proton Experimental or Glorious Eggroll’s releases. Lutris is the same, though I just default to the latest Glorious Eggroll release.